Research • Cardiovascular Network of Canada — CANet

Research

Enhancing Patients’ Care Pathways

CANet has over 97,000 patients enrolled in cardiac research programs and more than 200 investigators across Canada. Our Network conducts clinical research under three broad themes.

  • Technological innovations to improve the treatment of cardiac conditions.
  • Innovative, safe, and effective treatments to prevent
    1. sudden cardiac death;
    2. the progression of atrial fibrillation and related illness and death; and
    3. disabling syncope.
  • Effective solutions to promote a sustainable health system by empowering patients to manage their conditions.

Research from our Network has a significant impact on health and wealth creation in Canada.

We provide the biotechnology industry with opportunities to develop, test, and market new technologies and therapies for the diagnosis and treatment of cardiac arrhythmias. With our digital health initiatives, we capitalize on advances in computing power, internet-based communication, and accessible data to improve cardiac arrhythmia-related knowledge and care.

Our research partners include clinicians, biomedical and other researchers, engineers, industry and government, and most importantly, patients.

Patient-Led Research

From governance to research to cardiac disease management, patients are co-leaders in our Network.

We value and ensure patient partnership, their involvement, and their acceptance of research methodologies throughout the research cycle; from its conception to execution, from its implementation to evaluation. Their participation enriches research outcomes, allows patients to co-manage their cardiac arrhythmia disorders, and helps produce economic and social benefits for Canada.

There is an unprecedented opportunity to evaluate the impact of patient involvement on Network operations and outcomes. In doing so, we are adding to the growing science on patient engagement and providing evidence for future public policy development in healthcare delivery and innovation.

To learn more about our patient partners’ involvement, click here.

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RESEARCH PROGRAMS
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PATIENTS PARTICIPATING
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COMMERCIALIZED TECHNOLOGIES
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PATENTS FILED/ISSUED
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PARTNERS
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PARTNER MATCHED FUNDS

CANet Funded Projects/Programs

Project Title

Project Lead(s)

Project Track

CANet Funds

Matching Funds

STRATEGIC RESEARCH GRANT

Assessment of Norepinephrine Transport Inhibition to Prevent Recurrent Vasovagal Syncope (POST6)

Robert Sheldon, Satish Raj

Syncope

$249,929.00

$292,739.00

Canadian Syncope Risk Score - Optimal Management of Low-Risk Syncope Patients (CSRS)

Venkatesh Thirguanasambandamoorthy

Syncope

$730,344.00

$1,478,698.00

Remote Patient Management for Cardiac Implantable Electronic Devices (RPM-CIED)

Ratika Parkash

Sudden Cardiac Death

$231,200.00

$614,843.00

Atrial Image-guided Decision to Optimize Treatment of Atrial Fibrillation (AID-AF)

Allan Skanes , Frank Prato

Atrial Fibrillation

$496,200.00

$1,054,300.00

Early Invasive vs. Delayed Intervention for Atrial Fibrillation (EARLY-AF)

Jason Andrade

Atrial Fibrillation

$450,062.00

$1,667,000.00

The Canadian Genetic Heart Rhythm (CGHR) Network: Innovative Strategies to Reduce the Risk of Sudden Cardiac Death Using Novel Clinical and Population Approaches

Andrew Krahn , Robert Hamilton

Sudden Cardiac Death

$249,165.00

$355,000.00

Reducing Sudden Cardiac Death via ICT: Coordinated Use of Information and Communication Technologies (ICT) to Empower Patients and their Families to Reduce Sudden Cardiac Death Post Myocardial Infarction

Calum Redpath

Sudden Cardiac Death

$210,000.00

$235,000.00

Patient-Centered AF Management Program (PCAF)

Peter Leong-Sit , Ben Glover

Atrial Fibrillation

$171,903.00

$220,000.00

Community Alternatives for Syncope Management in the Emergency Room (CASMER)

Satish Raj

Syncope

$1,389,476.00

$563,166.00

Acute Myocardial Infarction Quality Assurance Study Canada (AMIQA)

Jaimie Manlucu , Stephen Wilton , Stephanie Frisbee

Sudden Cardiac Death

$342,549.00

$385,500.00

Decreasing Hospital Admissions from the Emergency Department for Acute Atrial Fibrillation

Ian Stiell , Debra Eagles

Atrial Fibrillation

$169,774.00

$60,000.00

Targeted Initiatives to Decrease the Burden of Sudden Cardiac Death in Canada – A CANet-CanROC Collaboration

Paul Dorian , Steven Lin

Sudden Cardiac Death

$1,246,941.00

$14,452,260.00

The Canadian Syncope Atlas (CANSync): A Tool for Surveillance, Patient Engagement and Monitoring

Roopinder Sandhu , Padma Kaul

Syncope

$329,996.00

$99,998.00

REMO-SYNC - Optimal Management of Low-Risk Syncope Patients — Phase 2

Venkatesh Thiruganasambandamoorthy

Syncope

$748,152.00

$1,675,481.00

VANISH 2

John Sapp

Sudden Cardiac Death

$523,540.00

$2,689,677.00

Improving the Care and Survival for Prehospital SCD Victims via Transformative Changes to 9-1-1 Ambulance Communication –Assisted CPR Instructions and the Development of Innovative Technology: A CANet-CanROC-Industry Partnership

Christian Vaillancourt

Sudden Cardiac Death

$999,641.00

$4,440,419.00

Decreasing Hospital Admissions from the Emergency Department for Acute Atrial Fibrillation — Phase 2

Ian Stiell

Atrial Fibrillation

$778,616.00

$1,536,000.00

Remote Patient Management for Cardiac Implantable Electronic Devices (RPM-CIED) — Phase 2

Ratika Parkash

Sudden Cardiac Death

$1,209,573.00

$3,182,836.00

MAJOR INDUSTRY-PARTNERED RESEARCH GRANT

Risk Estimation Following Infarction Noninvasive Evaluation - ICD efficacy (REFINE ICD)

Derek Exner

Sudden Cardiac Death

$2,575,000.00

$10,300,000.00

Resynchronization for Ambulatory Heart Failure Trial – LV Endocardial Approach (RAFT-LVendo)

Jaimie Manlucu

Sudden Cardiac Death

$600,000.00

$1,915,839.00

FOCUSED INVESTMENT PROGRAM / SOCIAL SCIENCES GRANT

Building Collaboration for a Sustainable Future

Cheryl Mitchell , Pam Ramsay

Atrial Fibrillation, Syncope, Sudden Cardiac Death

$45,000.00

$-

Mapping the Patient Journey

Mary Runte , Mark Speechly , Fiona Clement

$240,000.00

$-

Predictors of Perceived Self-Efficacy and Empowerment in Patients at Increased Risk of Sudden Unexpected Cardiac Arrest and their Caregivers

Colette Seifer

Sudden Cardiac Death

$109,978.00

$-

COMMERCIALIZATION GRANT

Catheter Contact-Force Controller for Cardiac Ablation Therapy

Daniel Gelman , Maria Drangova

Atrial Fibrillation

$300,000.00

$445,000.00

Catheter-Based Imaging Tools for Characterization of Myocardial Ablation Lesions

Brian Courtney

Atrial Fibrillation

$300,000.00

$360,000.00

Project Babelfish: A Transcutaneous Physiologic Sensor for Home and Clinical Use

Robert Sheldon

Syncope

$300,000.00

$-

An Autoimmune Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy

Robert Hamilton

Sudden Cardiac Death

$150,000.00

$-

AED on the Fly Program - An AED Drone Delivery Feasibility Study

Sheldon Cheskes

Sudden Cardiac Death

$150,000.00

$-

SEED GRANT

Development of Predictive Tests and Procedures for Risk Assessment of Sudden Death in Epilepsy

Robert Dumaine

Sudden Cardiac Death

$25,000.00

$-

Determining Processes of Care Associated with Improved Survival in Atrial Fibrillation Patients in Ontario, Canada

Sheldon Singh

Atrial Fibrillation

$25,000.00

$-

Simplified Home and Ambulatory Monitoring in Patients Evaluated for Inherited Arrhythmia (SHAPE - IA)

Andrew Krahn

Sudden Cardiac Death

$25,000.00

$-

Catheter Ablation for Atrial Fibrillation: Impact on Physical Activity, Quality of Life, and Burden of Arrhythmia

Benedict Glover

Atrial Fibrillation

$25,000.00

$50,000.00

IGNITE GRANT

Computer Simulated Atrial Fibrillation Tool to Reduce Hospitalizations and Emergency Department Visits

Ratika Parkash

Atrial Fibrillation

$25,000.00

$25,000.00

CHAT DISCOVERY GRANT

Catheter Contact-Force Control During Cardiac Ablation Therapy: In Vivo Evaluation

Daniel Gelman

Atrial Fibrillation

$25,000.00

$375,000.00

Big Data Analytics in Large AF Patient Databases: Correlates to Hospitalizations and ED Visits

Jiro Inoue

Atrial Fibrillation

$10,000.00

$-

SURFACE (in SUppoRt oF Ablation CandidatEs)

Katherine Allan

Atrial Fibrillation

$10,000.00

$31,500.00

Dilated Cardiomyopathy with Ataxia: Zebrafish as a Model to Understand the Pathophysiology of Sudden Cardiac Death

Saman Rezazadeh

Sudden Cardiac Death

$15,000.00

$-

The Effect of Frailty Assessment on Anticoagulation Rates in Elderly with Nonvalvular Atrial Fibrillation (UNFRAIL AF)

Zardasht Oqab

Atrial Fibrillation

$15,000.00

$-

Standard versus Intensive Monitoring Post-Myocardial Infarction Looking for New-Onset Atrial Fibrillation (SIMPL-AF) and Predictors of Poor Outcomes (SIMPL-PPO)

Christopher Cheung

Atrial Fibrillation

$25,000.00

$50,000.00

Redefining Electrical Storm Based on Clinical Outcomes: Data from the RAFT Trial

Ihab Elsokkari

Sudden Cardiac Death

$10,000.00

The Effects of HIIT on Time to Recurrence of Atrial Fibrillation After Electro – Cardioversion in Patients with Persistent Atrial Fibrillation: A Randomized Controlled Pilot Feasibility Trial

Lisa Cotie

Atrial Fibrillation

$15,000.00

$-

Trends in Clinical Outcomes After Out-of-Hospital Cardiac Arrest Due to Ischemic Heart Disease

Nigel Tan

Sudden Cardiac Death

$15,000.00

$10,000.00

Switching Off Cardiac Resynchronization Therapy in Non-Responders to Present Ventricular Arrhythmias and Related Hospitalizations: A Pilot Randomized Clinical Trial

Bishoy Deif

Sudden Cardiac Death

$15,000.00

$-

Auto-Antibodies in Brugada Syndrome: Validation and Assessment of a Novel Disease Marker

Meena Fatah

Sudden Cardiac Death

$25,000.00

$-

Left Atrial Function and Fibrosis After Successful Catheter Ablation for AF: A Pilot Study

Daniel Ramirez

Atrial Fibrillation

$15,000.00

$-

POST-DOCTORAL FELLOWSHIP PROGRAM

Investigating the Role of the Vectorcardiographically Derived QRS Area in CRT Response

Elien Engels

Other

$45,000.00

$45,000.00

Real-Time Localization of Ventricular Tachycardia Origin from the 12-Lead ECG

Shijie Zhou

Sudden Cardiac Death

$45,000.00

$45,000.00

CLINICAL FELLOWSHIP PROGRAM

Incidence Rate, Cardiac Symptoms, Circumstances, Triggers and Health Care Encounters Preceding Sudden Cardiac Death Caused by Hypertrphic Cardiomyopathy

Adaya Weissler-Snir

Sudden Cardiac Death

$60,000.00

$60,000.00

Structural, Functional and Autonomic Imaging of the Atrium in AF - Start Imaging AF

Stephen Duffet

Atrial Fibrillation

$60,000.00

$60,000.00

Decreasing Emergency Room Visits in Patients with Atrial Fibrillation Using the Digital Healthcare Platform of VIRTUES

Andrea Lee

Atrial Fibrillation

$60,000.00

$60,000.00

Dilated Cardiomyopathy with Ataxia: How can a Mitochondrial Transport Protein Mutation Result in Sudden Cardiac Death?

Saman Rezazadeh

Sudden Cardiac Death

$60,000.00

$60,000.00

IMPLEMENTATION GRANT

Ventricular Tachycardia Alation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease (VANISH)

John Sapp

Sudden Cardiac Death

$162,000.00

$-

Optimal Management of Low-Risk Syncope Patients

Venkatesh Thirguanasambandamoorthy

Syncope

$336,618.00

$-